The NewsYet – Researchers develop ‘one-two punch’ to destroy cancerous ovarian cells – ANI News
The NewsYet –
Updated:Jun 11, 2019 19:57IST
Washington DC [USA], June 11 (ANI): Researchers have developed a two-step combination therapy‘one-two punch’to destroy cancercells.
The study published in the journal ‘Nature Communications’ showed the superior therapeutic effectiveness of the‘one-two punch’oncellsofovariancancer patients, based on the manipulation of the state of cellular aging.
“In the case of epithelialovariancancer (EOC)–the most common and lethalovariancancer–we act in two stages. First, we force the cancercellsto age prematurely i.e., we force them into senescence. This is the first therapeutic punch. We throw our second punch using senolysis, destroying and eliminating them. This strategy requires excellent coordination of the two steps,” explained Francis Rodier, a researcher at the Universite de Montreal.
The team of researchers, led by Rodier and his colleague Anne-Marie Mes-Masson, discovered that EOCcellsenter senescence following chemotherapy in combination with PARP inhibitors. PARPs are enzymes that help repair damage to DNA. By blocking PARPs, PARP inhibitors prevent cancercellsfrom repairing their DNA, stop them from proliferating and cause them to age prematurely.
“Thanks to our‘one-two punch’approach, we have managed to destroy senescent EOCcellsin preclinicalovariancancer models. Our approach could improve the effectiveness of chemotherapy in combination with PARP inhibitors and counteract the systematic resistance that develops with this treatment,” said Mes-Masson, another researcher at the Universite de Montreal.
“Our ‘one-two punch strategy’ was also tested on preclinicalovarianand breast cancer models, which allowed us to validate its effectiveness,” commented Mes-Masson.
Although the results of this study will be used to propose clinical trials forovarianand triple-negative breast cancer, Rodier said that it is important to remember that they used preclinical models in which there was no immune system. “Given the importance of the immune response in humans, we need to continue evaluating our strategy in a context closer to biological reality.” (ANI)